First melanoma drug that prolongs life

An important discovery has been made in medical field: first melanoma drug that prolongs life. Bristol-Myers Squibb Company announced the discovery of the first medicine which administered to patients suffering from melanoma, promises to extend their life.

The medicine has already been approved by the Food and Drug Administration and released on the market. It’s called Yervoy and it’s administered by injection in late-stage or metastatic melanoma. The chemical name for the drug is ipilimumab, and until now it only had results in a small group of patients studied.

They lived an average of four months period of time longer than other patients. But researchers say the medicine is an significant step in treating the deadliest form of skin cancer, which most of the time is unresponsive to any kind of therapy. Tim Turnham, director of the Melanoma Research Foundation said: “Clearly this is not a home run, but it’s a solid base hit. And because we see other things in the pipeline, we think this the first in a series of important new therapies for melanoma.”
    Taking Yervoy can have several side effects, most of them affecting body immunity. Patients under treatment may show signs of rash, diarrhea, swelling of the colon or tiredness. Also severe negative reactions were found including irritation of the colon and small intestine, liver and skin.

Usually these side effects were noticed at patients, during their treatment, but some occurred even after ending treatment. 
    FDA has given their approval for releasing the drug based on a Bristol-Myers study of 676 people who have advanced, inoperable melanoma and already failed previous treatments, giving them a short extension of life span. Test consisted in administrating them one of three variants of treatment: ipilimumab by itself, ipilimumab combined with another immune-stimulating treatment, or the immune-stimulating treatment alone.

5 Worst Foods You Should Avoid

If you want to have a healthy digestion you have to know which are 5 worst foods you should avoid. Officials statistics recently released by Center for Disease Control and Prevention shows that more than 42 million medical visits are made due to the digestive problems.

Another alarming statistic is that about 95 million Americans suffer from poor digestion, the American College of  Gastroenterology says. If you want to avoid stomach problems like bowel syndrome, acid reflux, heartburn or ulcer, you should avoid the following foods and drinks:

1. Mint: Ironically, in some cases mint can have benefits in digestive issues, but sometimes can have exactly the reverse effect and  increase chances for heartburn. This effect can be caused by anything that contains mint such as tea or even peppermint gum.

2. Sodas and fruit juices: Like lactose intolerance, there is also fructose intolerance and that is a main cause in irritable bowel syndrome (IBS). There is a 30 percent of adults facing a fructose intolerance.

3. Beans: Contain a substance called oligosaccharide ( a type of complex sugar) which is very hard to be digested by your stomach, because the lack of enzyme necessary for doing that.

4. Coffee: Because of the acids it contains, drinking coffee can lead to indigestion and reflux, especially for those who already have ulcers or who are prone to heartburn.

5. Fatty foods: Well, this is not a surprise, we all know that foods high in fats are harmful for our stomachs. Because they stay in there for a longer period of time, your body has to work harder in order to digest the fats. Usually eating fatty foods causes delay in digestion and it stimulates extra acid secretion.

It’s not a solution to never eat these foods again, but it’s a wise thing to avoid them as much as possible. It is better to prevent that to treat.

Milk Allergy in Children

When occurs allergy to milk?

This type of allergy can occur at any time of life but is most common in infants. Between 2% and 3% of infants have a milk allergy,
which usually passes with time.

If you think your baby has a milk allergy, consult your doctor. There are tests that can diagnose the problem and there are
alternatives to powdered milk and dairy products – that your doctor can show you.

What is allergic to milk?

Milk allergy occurs when the child’s immune system mistakenly believes the protein in milk is dangerous and tries to fight against her.

This triggers an allergic reaction, which can cause restlessness and irritability of the child,an upset stomach and other symptoms.

Milk allergy occurs to breastfed babies?

Breastfed babies have a lower risk of allergy to milk than those who are fed  whit powdered milk, but researchers do not fully understand why
 some children are allergic to milk and some aren`t. It is considered that in many cases, the allergy is genetic.

When decreases the risk of allergy to milk?

Usually, milk allergy goes away in time until the age of 3-5 years, but some children never get rid of it.
 Milk allergy isn`t the same as lactose intolerance, an inability to digest lactose, rare in infants but more common in older
 children and adults.

Milk allergy symptoms

Symptoms of allergy to cow’s milk protein will  occur in the first months of life. Your baby may show symptoms immediately
after eating (rapid response) or after 7-10 days (slow reaction).

The most common reaction is slow. Symptoms may include loose stools (possibly bloody), vomiting, eructation (belching), refusing food,
irritability or colic, and skin rash.

This type of reaction is more difficult to diagnose because similar symptoms may occur with other health problems. Most children will
get rid of this form of allergy by age 2 years.

Rapid response occur suddenly with symptoms that can include irritability, vomiting, slow breathing, swelling, hives, all kinds of itchy
sores and bloody diarrhea.

In rare cases, can cause potentially severe allergic reaction called anaphylactic shock – which affects the skin, stomach, blood and baby’s
 breath. Anaphylaxis is more common in other types of allergies foods than cow’s milk.

Diagnosing an allergy to milk

If you suspect that your baby is allergic to milk, consult your doctor. Your doctor will likely ask about family history of allergy or
food intolerance that already exist in your family, then will make a physical exam to child.

There is no specific laboratory test to accurately diagnose a milk allergy, so your doctor may recommend a series of tests to diagnose and
eliminate other health problems.

Besides blood and stool tests, your doctor may recommend a skin allergy test in which a syringe is inserted under the skin surface  with a
small amount of cow’s milk protein . If you see a red patch called wheat, the child may be allergic to milk.

Your doctor may ask you to do a test diet. After a week in which you haven`t given milk to child, the doctor will ask again to give him milk,
 then wait several hours for an allergic reaction. Sometimes doctors repeat this test to reconfirm the diagnosis.

First full face transplant in US

Doctors from Brigham and Women’s Hospital, in Boston, succeeded first full transplant in US. A team of 30 doctors, anesthesiologists and nurses, led by plastic surgeon Dr. Bohdan Pomahac performed the complete face transplant which was a premiere in the United States.

The surgery lasted more than 15 hours, and it was a success. The patient was a Texas construction worker, named Dallas Wiens, who was totally disfigured in a power line accident in November 2008. The burns were so serious that literally erased his facial features.

Beside his lips, nose, eyebrows and eyelids he also lost his sight. The doctors managed to make a reconstruction and replace his facial skin, muscles of facial animation and also the nerves that power them and provide sensation. But they couldn’t restore his sight and it is not known yet if Wiens will be able to see again in the future.

For now, he is on his way to recovery and he even talked on the phone to his family. “He is doing great. He has been on the cellphone with his family and talking,” said Dr. Bohdan Pomahac, the one who led the transplant team.      

His donor was a recently dead person, which name and details remained unknown, respecting his family decision and also the patient confidentiality. “Today’s tremendous news marks a new milestone in Brigham and Women’s legacy in transplant surgery.

The pioneering achievement by the entire transplant team is a gift made possible by the most selfless act one human being can do for another, organ donation.” said hospital president Betsy Nable in a news conference that followed after the transplant. According to the doctors, Wiens new look will not resemble with the donor’s face or with his, it will actually be something between these two.

The donor was chosen by certain criteria like sex, age and blood type.
    The patient has a 3 years old daughter and his biggest motivation for the surgery was to feel her kisses and smile to her again. According to his family, Dallas Wiens wants to become an advocate for facial donations after he will be recovered.

Also they were grateful to the donor family: “You will forever remain in our hearts and our prayers and we are grateful for your selflessness.”    
    This was the third face transplant in the U.S., but the first two were only partial. First face transplant in the world was performed in 2005, in France and it was also a partial.

After 30 years a new weapon against melanoma!

After 30 years of failure, there is a new weapon effective against the most aggressive skin cancer, melanoma, and in Italy affects about 6,000 people each year and kills 1,500. He does not attack the tumor directly, but triggers the immune system. The results of experiments conducted in 125 centers worldwide and in which Italy has played an important role, were presented today at the Congress of the American Molecular Oncology (ASCO) being held in Chicago (Illinois). The molecule, called ipilimumab, reached its third phase of the trial. It is not a vaccine, but immunotherapy: “While a vaccine stimulates the immune system directly, this drug removes a block,” says the coordinator of the Italian branch of the study, Paul Ascierto, National Cancer Institute ‘Pascale’ Naples.
The molecule releases the molecular brake that normally stops the immune reaction at the right time. Consequently, the immune system are unleashed against any cancer cells. The results are considered so promising that in Italy, patients with advanced disease may have the drug for compassionate use (the top 20 in Naples). Some centers, finally, are testing the drug against cancer of the prostate and lung.

Pregnancy month by month: second month

After the excitement of the first month in which you found to be pregnant, today we’ll explain what happens in the second month of pregnancy. The first few weeks usually pass without symptoms and with almost no notice of your country, from the second month instead of the mother can begin the first symptoms or discomfort and nausea. To combat the nausea you should eat dry foods and especially in the morning, drink coffee, but do not strain used some anti-nausea food like ginger. They can also appear flushing, frequent urge to urinate, painful breasts, heartburn, headache, dizziness, nosebleeds, itching not take medication, consult your doctor.

The little annoyances however sidelined seeing the development and growth of your baby will move a lot. Do you think that your small in size, moving from 4 weeks to 8 mm to 3 cm. And it is the second month will begin to form all the organs of your baby: it begins to form the nervous system, lungs, liver, stomach and pancreas, spine, kidneys, muscles, and the first form.
At the end of the eighth week, the length of your baby will be about 3 cm for a weight of 2 or 3 grams. Finally unveil the first ultrasound your baby, but it will be difficult to distinguish the form for these early weeks, your doctor will check that the development is perfect.
From the seventh week onwards begins to distinguish the shape of the face and body of the child. This is one of the most exciting moment of the whole pregnancy!
Finally, remember that the first quarter is the most sensitive: avoid making too much effort and rest if you feel the need.

Biologics against Crohn’s disease

Crohn’s disease (or Crohn’s disease) can be stopped by early treatment with drugs biologists, can result in disease remission and heal the intestinal mucosa.
These research findings Sonic (Study of Biologic to immunomodulatory Naive Patients in Crohn’s Disease), published by The New England journal of Medicine.
The researchers examined 500 patients (from the USA, Israel and Europe) treated with infliximab, a biological drug. He then noted that the treatment had resulted in 70% of cases, mucosal healing and disease remission.
As experts point out, today’s approach against Crohn’s disease involves the use of steroids. But these substances, in addition to its efficacy, can cause unpleasant side effects
So, despite all due caution, many doctors look very favorably organic option proposed by SONIC.
For example, favorable treatment to Dr. Silvio Danese, head of the Center for Research and Treatment of inflammatory bowel disease IRCCS Istituto Humanitas Rozzano (MI).
Danish says: “Crohn’s disease has its greatest ally in time: every day spent without a fight effectively involves a new lesion, a new complication, a new damage. SONIC The study showed that the disease can be ‘and it must stop , changing the therapeutic approach and intervene immediately after diagnosis and after a failure with steroid therapy. The data are clear: over the years we have learned that the steroid and ‘a drug that should only be used when initiating treatment and then not possible because ‘produces side effects. And today we know that the only azathioprine, immunomodulator used in treating disease, not’ can block the progression of the disease. This study takes us one step forward and now we can say that use more ‘early infliximab alone or in combination, and’ patients’ right ‘(ie’ those with moderate to severe form), the way to go. ” Furthermore, the biological therapy is also positive for “The NHS: it reduces the need for surgery, thus reducing its hospital admissions, visits, examinations.
On the same wavelength Armuzzi Dr. Alexander, director of ‘Complex Operations of Internal Medicine and Gastroenterology, Columbus Integrated Complex University’ Cattolica in Rome. Armuzzi explains: “A great progress, because ‘in many cases so you get’ the regression of the disease and mucosal healing without steroid use, enabling better quality ‘of life for patients.”

A laboratory studies the human motion

Analyze human motion and articulation through a sensory system for detection. To meet the challenge is the Galliera Hospital in Genoa, which opened yesterday morning in the presence of top hospitals, the laboratory of Biomechanics and Motion Analysis. Directed by Dr. Claudio Mazzola, head of the complex structure of Orthopaedics of the joints, the laboratory – the first in Liguria and one of the few in Italy – has a sophisticated digital high definition (BTS SMART-D) that can capture any type of movement to carry out evaluation and diagnosis of the functional path and posture of athletes or not. “An instrument thus – explained the director Mazzola – which allows for very accurate surveys on human movement in order to identify the causes and consequences of any changes and anomalies. The biomechanical study of gestures engines is to perform a strategic evaluation pre-surgery and in recovery, in cases, for example, prosthesis of hip and knee ligament reconstructions, shoulder and ankle injuries. We are also able to provide technical assistance to improve the sport performance of athletes. “
And the demonstration came from light Emma Quaglia, Italian champion in 3000 m steeplechase, which wrapped sensors, yesterday measured the muscle activity and controlled in real-time results to a computer, simulating jump and walk under the watchful eye cameras. In the new structure, located on the first floor of Hall C in the course Mentana, were in fact installed 12 infrared cameras which detect body movements, the system is also equipped with two platforms for the assembly of forces expressed by walking, running and Skip these. “With the activation of the laboratory – said Lagostena Adriano, general manager of the Galleria – we provide innovative technology, coupled with highest level of expertise, allows us to offer an exclusive service in clinical application in the research and sport. ” Unofficially the center is ready, were in fact tested several athletes, but officially opens to the entire population health by next summer, after receiving accreditation from the region. “A laboratory that has a social meaning – concluded Mazzola – not only directed at sports league, but also to the pensioner that comes with knee problems. Everyone will use it by paying the ticket, or by evaluation of orthopedic physiatric. These machines that we use today will then be transferred to the new hospital Galliera.

Health spending continues to grow …

In the first quarter of 2010, the National Health Insurance Fund recorded an increase of 4.1% in expenditures compared to the same period last year.
These are the care reimbursements city that have particularly increased (+4%). Thus, care paramedics recorded an increase of 8.2% in first quarter 2010 against 7% over the last twelve months.
Per diems are also strong growth: + 6.1% in the first quarter of 2010 against 4.8% in the last 12 months. Strong growth “due to payments associated with the epidemic of influenza A at the end of 2009” reads the study of the CNAM. Indeed, the month of March, the trend is consistent with the annual change (+4.8%).
In contrast, expenditure on medical and dental fees rose more slowly in the first quarter 2010 (+0.9% against +1.8% over the last twelve months). This slowdown is partly due to an epidemic lower early this year.

Eat less, live longer and healthier

A research team from the United Kingdom has just discovered that we can extend our life expectancy by eating fewer calories each day. The results of this study, published in the journal Science, show that caloric restriction is reflected not only by prolonging life, but also through better health, because we can prevent many diseases associated with age.

The research team from University College London, United Kingdom, Davis School of Gerontology at the University of Southern California (USC) and Washington University School of Medicine in St Louis, United States, conducted tests of calorie restriction in rodents and found that these dietary restrictions had a significant impact on the molecular pathways related to aging process.

The results also showed that in less complex organisms, caloric restriction could double or even triple the life. But the study’s lead author, Dr. Luigi Fontana, Faculty of Medicine, University of Washington, said that the primary objective of the research was to improve our quality of life and help us avoid diseases associated with aging.

“The goal of my research is not really extend the lifetime up to 120 or 130 years,” he explained. “Currently, the average life expectancy in Western countries is about 80 years, but most people are in good health until age 50. We want to use these findings on caloric restriction and other genetic or pharmacological interventions related to bridge this gap of 30 years between life expectancy and ‘life expectancy in good health. ” However, extending the duration of healthy life, the average life expectancy may also increase up to 100 years. “

The researchers reduced the caloric intake of rodents by 10 to 50%, resulting in reduced activity of pathways involving growth factor similar to insulin (IGF-1) and glucose. Such a reduction in calories has significantly increased the lifespan of rodents, and reduce their susceptibility to age-related diseases such as cancer, cardiovascular disease and cognitive problems.

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